The Journal of Immunology

Lpar5 regulates the CD8 T-cell response to persistent virus infection by altering exhaustion programming, survival, and NK receptor expression

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J Immunol. 2025 Aug 29:vkaf210. doi: 10.1093/jimmun/vkaf210. Online ahead of print. ABSTRACT Persistent antigen exposure during chronic viral infection and tumor development drives CD8 T cells into an exhausted, hypofunctional state. Understanding the molecular pathways that enforce T-cell exhaustion is critical for improving current immunotherapies. Previously, we have shown the bioactive lipid lysophosphatidic acid (LPA) … Read more

Cell death in the brain during parasitic infections

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J Immunol. 2025 Aug 1;214(8):1881-1888. doi: 10.1093/jimmun/vkaf128. ABSTRACT Programmed cell death is an integral arm of immunity, especially in response to intracellular pathogen infection, for the release of inflammatory mediators, and the clearance of pathogen-infected cells. In the central nervous system, cell death as a form of immunity may seem paradoxical; neuronal health is critical … Read more

From defense to disease: the multifaceted role of lymphatics during infection

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J Immunol. 2025 Aug 1;214(8):1863-1871. doi: 10.1093/jimmun/vkaf116. ABSTRACT The lymphatics are a system of vessels that traffic lymph and immune cells throughout the body to maintain fluid balance and aid in the response to infection and injury. Although the lymphatics are often thought of as a passive conduit, this review will demonstrate that the lymphatics … Read more

Enhanced affinity for the IL-2 receptor β subunit potently increases antitumor efficacy of IL-2 across various tumor models by reshaping the tumor microenvironment

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J Immunol. 2025 Aug 28:vkaf208. doi: 10.1093/jimmun/vkaf208. Online ahead of print. ABSTRACT The main limitations of cancer treatment with high doses of recombinant interleukin 2 (IL-2) are high toxicity and the undesired expansion of regulatory T cells. The generation of IL-2 mutated variants (muteins) with changes in the affinity for different chains of the IL-2 … Read more

Malat1 regulates female Th2 cell cytokine expression through controlling early differentiation and response to IL-2

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J Immunol. 2025 Aug 28:vkaf177. doi: 10.1093/jimmun/vkaf177. Online ahead of print. ABSTRACT Identifying cell intrinsic regulators of immune sexual dimorphism is critical for treatment of several immunopathologies. We show that Malat1 is required for appropriate cytokine expression in female but not male T helper 2 (Th2) cells. Malat1 deficiency impairs in vitro Th2 differentiation of … Read more

The ability of memory CD8 T cell subsets to numerically and functionally recover following whole body irradiation is influenced by their history of cognate antigen exposures

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J Immunol. 2025 Aug 25:vkaf194. doi: 10.1093/jimmun/vkaf194. Online ahead of print. ABSTRACT As a result of the growing use of nuclear energy and radiation in medical interventions within the last decade, the potential for radiation exposure among the general public has increased. Exposure to high doses of radiation severely impairs the immune system, including CD8 … Read more

ACLY promotes NK cell effector function by regulating glycolysis and histone acetylation

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J Immunol. 2025 Aug 25:vkaf209. doi: 10.1093/jimmun/vkaf209. Online ahead of print. ABSTRACT Natural killer (NK) cells are innate immune lymphocytes important for host viral and tumor immunity. We investigated the requirement for ATP citrate lyase (ACLY) in NK cell function using an inducible genetic mouse model. ACLY regulates the citrate-malate shuttle, generating cytosolic acetyl-coenzyme A … Read more

Harnessing CD39 inhibition to boost antitumor immunity with extracellular ATP

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J Immunol. 2025 Aug 24:vkaf187. doi: 10.1093/jimmun/vkaf187. Online ahead of print. ABSTRACT CD39 (encoded by ENTPD1) has emerged as a target for oncologic therapies. Inhibition of CD39 preserves extracellular adenosine triphosphate (eATP) and decreases extracellular adenosine (eADO) formation, thereby increasing the eATP/eADO ratio and promoting immune stimulation. RNA expression profiling of eATPases across all solid … Read more

Establishment of a mouse model of Sjögren syndrome-related interstitial lung disease

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J Immunol. 2025 Aug 24:vkaf211. doi: 10.1093/jimmun/vkaf211. Online ahead of print. ABSTRACT Sjögren syndrome-related interstitial lung disease (SS-ILD) is a severe complication associated with significant morbidity and mortality. Despite its clinical importance, the underlying pathogenesis remains poorly understood, and effective therapeutic strategies are limited. The development of a reliable animal model for SS-ILD is crucial … Read more

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