J Immunol. 2024 Sep 25:ji2400292. doi: 10.4049/jimmunol.2400292. Online ahead of print. ABSTRACT Vitamin D status, the vitamin D receptor (VDR), and the ability to produce active vitamin D [1,25(OH)2D, regulated by Cyp27b1] regulate fetal and adult hematopoiesis. Transgenic reporter mice that express the tdTomato RFP as an indication of Vdr expression were used to identify … Read more
J Immunol. 2024 Sep 25:ji2400228. doi: 10.4049/jimmunol.2400228. Online ahead of print. ABSTRACT G protein-coupled receptors (GPCRs) represent the largest family of surface receptors and are responsible for key physiological functions, including cell growth, neurotransmission, hormone release, and cell migration. The GPCR 56 (GPR56), encoded by ADGRG1, is an adhesion GPCR found on diverse cell types, … Read more
J Immunol. 2024 Sep 23:ji2400417. doi: 10.4049/jimmunol.2400417. Online ahead of print. ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis, is one of the leading causes of death due to an infectious agent. Coinfection with HIV exacerbates M. tuberculosis infection outcomes in people living with HIV. Bacillus Calmette-Guérin (BCG), the only approved TB vaccine, is effective in … Read more
J Immunol. 2024 Sep 23:ji2400253. doi: 10.4049/jimmunol.2400253. Online ahead of print. ABSTRACT IL-7 is a cytokine produced by stromal cells, which binds to IL-7Rα and plays an important role for homeostasis of T lymphocytes. Excessive activities of IL-7-triggered signaling pathways causes autoimmune diseases. How IL-7-triggered signaling and immune effects are regulated is not fully understood. … Read more
J Immunol. 2024 Sep 23:ji2400138. doi: 10.4049/jimmunol.2400138. Online ahead of print. ABSTRACT Intraepithelial lymphocytes (IELs) expressing the TCRγδ survey the intestinal epithelium to limit the invasion of microbial pathogens. The production of type I IFN is a central component of an antiviral immune response, yet how these proinflammatory cytokines contribute to γδ IEL effector function … Read more
J Immunol. 2024 Sep 20:ji2400196. doi: 10.4049/jimmunol.2400196. Online ahead of print. ABSTRACT Pre-eclampsia (PE) affects 5-8% of pregnancies and has detrimental effects on maternal-fetal health. PE is characterized by de novo hypertension after 20 wk of gestation and end-organ damage. Systemic inflammatory imbalance has been associated with PE, but its contribution to the pathology is … Read more
J Immunol. 2024 Sep 20:ji2400331. doi: 10.4049/jimmunol.2400331. Online ahead of print. ABSTRACT Expression of IL-15 on the surface of human graft endothelial cells (ECs) bound to the IL-15Rα subunit can increase the activation of CTLs, potentiating allograft rejection. Our previous work showed that surface expression of this protein complex could be induced by alloantibody-mediated complement … Read more
J Immunol. 2024 Sep 20:ji2400146. doi: 10.4049/jimmunol.2400146. Online ahead of print. ABSTRACT Alemtuzumab induction with belatacept/rapamycin-based maintenance immunotherapy (ABR) prevents kidney allograft rejection and specifically limits early costimulation blockade-resistant rejection (CoBRR). To evaluate the mechanisms by which this regimen alters CoBRR, we characterized the phenotype and functional response of preexisting memory cells to allogeneic endothelial … Read more
J Immunol. 2024 Sep 18:ji2400035. doi: 10.4049/jimmunol.2400035. Online ahead of print. ABSTRACT Innate immune responses such as phagocytosis are critically linked to the generation of adaptive immune responses against the neoantigens in cancer and the efferocytosis that is essential for homeostasis in diseases characterized by lung injury, inflammation, and remodeling as in chronic obstructive pulmonary … Read more
