The Journal of Immunology

Topoisomerase 1 is required for the development and function of thymus

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J Immunol. 2025 Jan 1;214(1):23-39. doi: 10.1093/jimmun/vkae003. Epub 2025 Jan 23. ABSTRACT Thymus organogenesis is critical for proper maturation of developing T cells. In this study, we identified Topoisomerase 1 (Top1) as a novel gene involved in thymus development and function. We created a mouse line with deletion of Top1 in thymic epithelial cells (TECs) … Read more

Hypoimmunogenic HLA-E Single Chain Inhibits Alloreactive Immune Responses

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J Immunol. 2024 Dec 15;213(12):1799-1810. doi: 10.4049/jimmunol.2400491. ABSTRACT Chimeric Ag receptor T cells derived from universal donors are susceptible to recipient immunologic rejection, which may limit their in vivo persistence and compromise treatment efficacy. In this study, we generated HLA class I-deficient T cells by disrupting β2-microglobulin to evade recognition by HLA-mismatched CD8+ T cells, … Read more

An Insight into the Role of IL-10 and Foamy Macrophages in Infectious Diseases

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J Immunol. 2024 Dec 15;213(12):1729-1737. doi: 10.4049/jimmunol.2400033. ABSTRACT Dysregulation of lipid homeostasis causes the deposition of lipids in the form of tiny droplets within foamy macrophages (FMs). In FMs, host-derived lipids aid in survival of various intracellular pathogens leading to sustained infection. In several infectious diseases, the transformation of macrophages into a foamy phenotype is … Read more

IgG Glycosylation: Biomarker, Functional Modulator, and Structural Component

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J Immunol. 2024 Dec 1;213(11):1573-1584. doi: 10.4049/jimmunol.2400447. ABSTRACT The family of IgG Abs is a crucial component of adaptive immunity. Glycosylation of IgG maintains its structural integrity and modulates its effector functions. In this review, we discuss IgG glycosylation covering cell biological as well as therapeutic and disease-related aspects, focusing on the glycan structures in … Read more

Ubiquitination of Hemocyanin Mediated by a Mitochondrial E3 Ubiquitin Ligase Regulates Immune Response in Penaeus vannamei

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J Immunol. 2024 Nov 8:ji2400493. doi: 10.4049/jimmunol.2400493. Online ahead of print. ABSTRACT Ubiquitination is a critical posttranslational modification that regulates host immune responses to pathogens. In this study, we investigated the ubiquitination of hemocyanin (PvHMC [Penaeus vannamei hemocyanin]) mediated by the mitochondrial E3 ubiquitin ligase (PvMulan) in shrimp Penaeus vannamei. We characterized distinct ubiquitination patterns … Read more

Diverse Epithelial Lymphocytes in Zebrafish Revealed Using a Novel Scale Biopsy Method

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J Immunol. 2024 Nov 6:ji2300818. doi: 10.4049/jimmunol.2300818. Online ahead of print. ABSTRACT Zebrafish (Danio rerio) are a compelling model for studying lymphocytes because zebrafish and humans have similar adaptive immune systems, including their lymphocytes. Antibodies that recognize zebrafish proteins are sparse, so many investigators use transgenic, lymphocyte-specific fluorophore-labeled lines. Human and zebrafish lymphocyte types are … Read more

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