Trends Immunol. 2025 Apr 11:S1471-4906(25)00058-4. doi: 10.1016/j.it.2025.02.015. Online ahead of print. ABSTRACT In the germinal center (GC), B cells undergo rounds of somatic hypermutation (SHM), proliferation, and positive selection to develop into high-affinity, long-lived plasma cells and memory B cells. It is well established that, upon activation, B cells significantly alter their metabolism, but until … Read more
Trends Immunol. 2025 Mar 31:S1471-4906(25)00059-6. doi: 10.1016/j.it.2025.03.001. Online ahead of print. ABSTRACT While highlighting the complexity and heterogeneity of tumor immune microenvironments, the application of single-cell analyses in human cancers has identified recurrent subsets of tumor-associated macrophages (TAMs). Among these, interleukin (IL)-1β+ TAMs – cells with high levels of expression of inflammatory response and tissue … Read more
Trends Immunol. 2025 Mar 27:S1471-4906(25)00076-6. doi: 10.1016/j.it.2025.03.002. Online ahead of print. ABSTRACT The ongoing evolution of SARS-CoV-2 poses significant challenges to existing neutralizing antibodies and vaccines through immune escape mutations. By leveraging genomic surveillance and antibody deep mutational scanning (DMS) data, Raharinirina and colleagues developed a computational framework to elucidate region-specific SARS-CoV-2 variant dynamics and … Read more
Trends Immunol. 2025 Mar 24:S1471-4906(25)00057-2. doi: 10.1016/j.it.2025.02.014. Online ahead of print. ABSTRACT Cancer is increasingly prevalent worldwide, often coexisting with type 2 diabetes (T2D). Recent breakthroughs reveal the immune system’s pivotal role in eliminating tumors and how the metabolic environment, such as glucose availability, affects antitumor immunity. Diabetes is known to dysregulate both innate and … Read more
Trends Immunol. 2025 Mar 22:S1471-4906(25)00052-3. doi: 10.1016/j.it.2025.02.009. Online ahead of print. ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains one of the leading causes of death worldwide. TB pathogenesis is shaped by a complex interaction between the pathogen and host immune responses, particularly through mechanisms such as oxidative stress and ferroptosis; a form of … Read more
Trends Immunol. 2025 Mar 19:S1471-4906(25)00053-5. doi: 10.1016/j.it.2025.02.010. Online ahead of print. ABSTRACT Various mammalian CD8+ T cell subsets with regulatory properties are either formed through a thymus-dependent mechanism or induced under various experimental protocols and referred to as CD8+ regulatory T cells (Tregs). CD8+ Tregs maintain distinct functions in the presence of CD4+ Tregs. This … Read more
Trends Immunol. 2025 Mar 19:S1471-4906(25)00055-9. doi: 10.1016/j.it.2025.02.012. Online ahead of print. ABSTRACT The devastating impact of respiratory infections demonstrates the critical need for novel prophylactic vaccines. In this opinion article, we advocate for bacterial immunotherapies as a complementary tool in our fight against respiratory infections. These immunotherapies can activate a wide spectrum of immunological mechanisms, … Read more
Trends Immunol. 2025 Mar 19:S1471-4906(25)00054-7. doi: 10.1016/j.it.2025.02.011. Online ahead of print. ABSTRACT Microglia, key orchestrators of the brain’s immune responses, play a pivotal role in the progression of Alzheimer’s disease (AD). Emerging human models, including stem cell-derived microglia and cerebral organoids, are transforming our understanding of microglial contributions to AD pathology. In this review, we … Read more
Trends Immunol. 2025 Mar 18:S1471-4906(25)00056-0. doi: 10.1016/j.it.2025.02.013. Online ahead of print. ABSTRACT IFN-γ is a pleiotropic antiviral cytokine that coordinates innate and adaptive immune responses and induces both immunostimulatory and immunosuppressive activities, limiting its use in the clinic. Due to its antiviral role, several viruses express proteins that bind IFN-γ, blocking its interaction with the … Read more
Trends Immunol. 2025 Mar 12:S1471-4906(25)00032-8. doi: 10.1016/j.it.2025.02.005. Online ahead of print. ABSTRACT Patients with an inborn error of immunity (IEI) often show a complete penetrance of their disease-causing mutation, whereas other forms of IEI show a family pattern where many family members carrying the same mutation remain unaffected. The underlying mechanism, differential allele-specific expression, was … Read more
