Trends in Immunology

Trends Immunol. 2025 Jan 30:S1471-4906(25)00001-8. doi: 10.1016/j.it.2025.01.001. Online ahead of print. ABSTRACT Tumor-infiltrating regulatory T (TI-Treg) cells constitute key components within the tumor microenvironment (TME) to suppress antitumor immunity and facilitate tumor progression. Although multiple therapies have been developed to eliminate TI-Treg cells, most of them exhibit only modest efficacy and harbor risks of inducing … Read more

Trends Immunol. 2025 Jan 28:S1471-4906(25)00022-5. doi: 10.1016/j.it.2025.01.004. Online ahead of print. ABSTRACT Mayassi and colleagues utilized spatial transcriptomics to create a comprehensive blueprint of the mouse gut, exploring its adaptability and resilience under perturbed conditions. Their work highlights the adaptive capabilities of the murine gut’s regionalized structure, providing insights into how it functions in a … Read more

Trends Immunol. 2025 Jan 27:S1471-4906(25)00002-X. doi: 10.1016/j.it.2025.01.002. Online ahead of print. ABSTRACT Chronic inflammatory diseases show significant heterogeneity in their phenotypes, with diverse immune cells and mediators interacting in response to various stimuli. This review proposes the concept of the ‘inflammazone’ framework – which maps the distribution of immune components driving disease pathogenesis – using … Read more

Trends Immunol. 2025 Jan 27:S1471-4906(25)00023-7. doi: 10.1016/j.it.2025.01.005. Online ahead of print. ABSTRACT Lim and colleagues demonstrate that synNotch transcriptional circuits engineered into T cells can be used to precisely control location-specific expression of payloads responding to antigen triggers, thus locally inhibiting unwanted immunity or neuroinflammation. With no off-tumor toxicity or systemic immunosuppression upon elimination of … Read more

Trends Immunol. 2025 Jan 23:S1471-4906(24)00308-9. doi: 10.1016/j.it.2024.12.006. Online ahead of print. ABSTRACT Ovarian cancer (OC) is the most lethal gynecologic malignancy, characterized by multiple histological subtypes, each with distinct pathological and clinical features. Current treatment approaches include cytotoxic chemotherapies, poly(ADP-ribose) polymerase (PARP) inhibitors, bevacizumab, hormonal therapy, immunotherapy, and antibody-drug conjugates (ADCs). In this review we … Read more

Trends Immunol. 2025 Jan 21:S1471-4906(24)00307-7. doi: 10.1016/j.it.2024.12.005. Online ahead of print. ABSTRACT Conventional dendritic cells (cDCs) are sentinels of the mammalian immune system that sense a wide range of danger and homeostatic signals to induce appropriately targeted T cell immune responses. Traditionally classified into two main subsets, cDC1 and cDC2, recent research shows that cDC2s … Read more

Trends Immunol. 2025 Jan 21:S1471-4906(24)00306-5. doi: 10.1016/j.it.2024.12.004. Online ahead of print. ABSTRACT Community engagement is essential for shaping equitable biomedical research priorities, but it is often underutilized, especially for marginalized populations. To integrate community feedback from the public into research, herein we describe a collaborative pilot funded by the Chan Zuckerberg Initiative which pairs the … Read more

Trends Immunol. 2025 Jan 7:S1471-4906(24)00305-3. doi: 10.1016/j.it.2024.12.003. Online ahead of print. NO ABSTRACT PMID:39779379 | DOI:10.1016/j.it.2024.12.003

Trends Immunol. 2024 Dec 27:S1471-4906(24)00299-0. doi: 10.1016/j.it.2024.11.014. Online ahead of print. ABSTRACT Immune checkpoint inhibitors (ICIs) have transformed cancer treatment but are frequently associated with immune-related adverse events (irAEs). This article offers a novel synthesis of findings from both preclinical and clinical studies, focusing on the molecular mechanisms driving irAEs across diverse organ systems. It … Read more

Trends Immunol. 2024 Dec 27:S1471-4906(24)00297-7. doi: 10.1016/j.it.2024.11.012. Online ahead of print. ABSTRACT Diverse macrophage populations inhabit the rodent and human central nervous system (CNS), including microglia in the parenchyma and border-associated macrophages (BAMs) in the meninges, choroid plexus, and perivascular spaces. These innate immune phagocytes are essential in brain development and maintaining homeostasis, but they … Read more