Precisely how diet regulates intestinal immunity and barrier function remains underexplored. Yu et al. identify a link between nutrient signals and host defense directed by diet-induced, GSDMD-mediated epithelial-immune co-adaptation. This study contri…
Pandey et al. identify Cathepsin S (CTSS) as the direct protease that cleaves Gasdermin C (GsdmC) in the intestine. Type 2 immune-promoting microbes trigger CTSS-dependent GsdmC activation in intestinal epithelial cells, targeting Rab7+ vesicles, alter…
(Immunity 54, 291–307.e1–e7; February 9, 2021)
Upon pathogen detection, phagocytes trigger immunity. This process induces tissue stress and the formation of host-derived molecules that further tune immune responses. We show that host-derived oxidized phospholipids accumulate upon microbial encounte…
Physical cellular interactions are crucial yet remain challenging to investigate in vivo. Deng et al. develop CINTER-seq, a chemical tool enabling in situ capture and multimodal profiling of interacting cells in living mice, uncovering specific LAG3-MH…
The brain meninges maintain self-tolerized B cells, but the pathological consequences of breaking this tolerance are unknown. Wang et al. reveal that autoreactive leptomeningeal B cells drive neuroinflammation by engaging pathogenic T cells and amplify…
While the immune response to Plasmodium falciparum malaria has been studied extensively, the circulating proteome and its cellular origins remain poorly characterized. Lautenbach et al. address this by integrating plasma proteomics and single-cell RNA-…
Macrophages can foster pro- or anti-tumor immune environments. In this issue of Immunity, Clark et al. report that altering the composition of the mitochondrial electron transport chain reprograms macrophages toward a CXCL9hiSPP1lo immunostimulatory ph…
The induction of CD4+Foxp3+ regulatory T cells (pTreg cells) in the intestine is important for preventing allergic and inflammatory disease, but what cells drive their differentiation is less clear. Three manuscripts in Nature, Cell, and Science conclu…
Autonomic imbalance is central to heart failure (HF), but the mechanistic impact of parasympathetic withdrawal has remained unclear. Li, Zhang, Li, et al. demonstrate that targeted optogenetic stimulation of choline acetyltransferase (ChAT)-expressing …
