Lack of CD4+ T cell help during acute infections is known to compromise the generation of functional CD8+ T cell memory. van der Heide et al. reveal that this dysfunction is not permanent but rather a transient state of delayed memory maturation. They …
(Immunity 51, 522–534.e1–e7; September 17, 2019)
The APOE3 Christchurch mutation (R136S) reduces tau pathology despite the PSEN1 mutation and high amyloid, though its protective mechanism remains unclear. Naguib et al. show that R136S suppresses microglial cGAS-STING-IFN signaling in tauopathy mice. …
While BCG is the standard therapy for bladder cancer, its clinical limitations demand improved strategies. Jurado et al. show that combining BCG with β-glucan reprograms granulopoiesis to generate trained neutrophils with enhanced antitumoral activity,…
Upon reactivation, some memory B cells differentiate into protective antibody-secreting cells. Risley et al. show that the transcription factor T-bet marks a population of memory B cells poised to rapidly differentiate into antibody-secreting cells. Th…
The impact of risk factors for severe infections (being old, male, obese, and having comorbidities) on immune dysregulation prior to infection remains understudied. Using 12,026 blood samples, Ganesan et al. showed that their previously described 42-ge…
Maintaining immune tolerance to the microbiota is essential for gut health. Zhou et al. demonstrate that ILC3s are a RORγt+ APC that sense the microbiota through STING to induce microbiota-specific Treg cells. However, if this pathway becomes uncontrol…
Although autoreactive CD8+ T cells kill melanocytes in vitiligo, the underlying mechanisms remain elusive, and effective therapeutic drugs are lacking. Yang et al. reveal that nociceptor-derived CGRP strengthens cDC1-CD8+ T cell interactions, leading t…
Human γδ T cells recognize pathogens and tumors through butyrophilin-mediated phosphoantigen sensing. However, the assembly of butyrophilin multimers and their mechanism of TCR engagement have remained unclear. Zhang et al. reveal cryo-EM structures sh…
Cytotoxic antibodies have become an essential tool to remove unwanted cells in patients with cancer, infection, and autoimmunity. Wöhner and Nimmerjahn summarize recent insights into how antibody-dependent cellular cytotoxicity (ADCC) reactions proceed…
