Particle exposure drives inflammation through unknown regulatory mechanisms. Cobo et al. identified a bifurcated transcriptional response in macrophages: an AMPK-TFEB/TFE3-DNMT3A/DOT1L axis controlling lysosomal acidification and a JNK-AP-1 pathway dri…
(Immunity 50, 418–431.e1–e6; February 19, 2019)
Central nervous system malignancies include primary tumors and brain metastases (BrMs) originating from extracranial cancers. Bejarano et al. examine primary and metastatic brain tumors and find distinct vascular alterations in IDH mutant gliomas, IDH …
Memory B cells (MBCs) emerging from germinal centers (GCs) are crucial for antibody-based vaccines. Luo, Hou, et al. find that T cell-derived interleukin-9 promotes expression of the transcriptional repressor ZBTB18 in GC B cells. ZBTB18 represses the …
VEGF blockade is known to enhance immune checkpoint blockade (ICB) efficacy, but its precise immunological mechanism remains undefined. Benmebarek et al. reveal that VEGF inhibition drives BAFF- and IL-12-dependent Treg reprogramming, promoting a fragi…
Neuroimmune regulation modulates responses to cardiovascular stress and injury. In this issue of Immunity, Perrotta et al. delineate a heart-brain-spleen axis that induces adaptive cardiac remodeling in response to pressure overload, highlighting a SPe…
The factors that modulate the inflammatory response in atherosclerosis are not well defined. In this issue of Immunity, Asare et al. examine the impact of a cis-regulatory element (CRE) that controls expression of HDAC9 and find that HDAC9-mediated dea…
In their letter to Immunity, Degli-Esposti and colleagues1 discuss the potential origins of tissue-resident natural killer (trNK) cells and the inflammatory contexts enabling their differentiation. These largely unresolved issues are relevant for NK-ba…
A recent study by Gasteiger and colleagues1 described a population of circulating natural killer (NK) cells that are recruited and retained in the skin for several weeks following local viral (vaccinia virus) and bacterial (Staphylococcus aureus) infec…
Lactate shows immunomodulatory properties. Mauro et al. review how lactate serves a fuel for the TCA cycle and an immunomodulatory molecule with context-dependent effects, and how its immunomodulatory properties are mediated via sensing through transpo…
