Franken et al. examine the mechanisms that differentiate combined therapy with anti-CTLA4 and anti-PD-L1 from anti-PD-L1 monotherapy in head and neck squamous cell carcinoma (HNSCC). Single-cell analyses of the tumor microenvironment, tumor-draining ly…
Influenza neuraminidase (NA) is underappreciated as a vaccine target owing to its incomplete epitope landscape. Lederhofer et al. isolated human monoclonal antibodies to NA underside (i.e., dark side) epitopes with broad cross-reactivity across N2 subt…
Innate immune cells tailor responses to specific stimuli via the selective activation of hundreds of genes. Feng et al. examine inducible nucleosome remodeling in response to TLR4 stimulation and reveal a unique requirement for NF-κB. Collaboration bet…
How cells induce the production of antiviral molecules while shutting down protein translation to limit viral replication remains unclear. Here, Harioudh et al. show a non-canonical function for the interferon-induced antiviral protein, OAS1, which seq…
Our understanding of how metabolites in the tumor microenvironment impact tumor-intrinsic immune responses remains incomplete. Here, Ding et al. reveal that lactate triggers RNA-splicing-mediated CTLA-4 expression in tumor-infiltrating Treg cells, whic…
SARS-CoV-2 mRNA-based vaccine-induced immunity is thought to wane quickly based on short-term studies. Using longitudinal data, Srivastava et al. find that participants with hybrid immunity show faster, higher antibody responses after initial vaccinati…
While Na+/K+-ATPase (NKA) plays important roles in the CNS, its role in microglia is unclear. Huang et al. find that NKAα1 inhibits microglia activation by forming a complex with P2X7R. Stress decreases membrane expression of NKAα1, facilitating P2X7R-…
LAG-3, TIM-3, and TIGIT comprise the next generation of immune checkpoint receptors being harnessed in the clinic.In this review, Joller et al. review advances in our understanding of the specialized functions of LAG-3, TIM-3, and TIGIT, focusing on th…
Diabetes is known to increase susceptibility to respiratory infections, but the underlying basis remains elusive. In a recent study in Nature, Nobs et al. showed that hyperglycemia impinges on the histone acetylation landscape to impair the ability of …
Disease-associated microglia (DAMs) are a unique microglial state in development and various CNS pathologies. In this issue of Immunity, Lan and colleagues provide novel insights into the diversity of DAMs in CNS diseases, revealing their terminal fate…
