During chronic inflammation, regulatory T (Treg) cells fail to effectively control effector T cells due to unresolved mechanisms. Here, Neuwirth and Malzl et al. identify the polyamine catabolic enzyme SSAT as a key driver of Treg cell dysfunction, whi…
Circulating memory CD8+ T cells are thought to be highly dependent on interleukin (IL)-7 signaling. Using inducible Il7ra deletion in circulating and tissue-resident memory CD8+ T cell subsets, Jarjour et al. reveal resilience to loss of IL-7 signaling…
The polyclonal CD8+ T cell response to a single antigen is the average of several hundred individual T cell clonotypes. Abdullah et al. demonstrate that most clonotypes exhibit TCR-intrinsic differentiation biases toward memory or effector fates and ar…
Maintaining blood sterility during urinary tract infections is crucial for preventing urosepsis. Li et al. identify a subset of bladder-resident suburothelial perivascular macrophages that is essential for restricting systemic uropathogen dissemination…
Innate immune signaling pathways are traditionally considered to be intracellular. Huai et al. show that the RNA-sensing OAS-RNase L pathway can initiate in one cell and complete in another cell through the transfer of second messenger, 2-5A, acting as…
How innate immune signaling within neurons influences neurotransmission remains poorly understood. Estevez et al. show that the necroptotic kinase RIPK3 promotes neuronal survival during viral infections of the central nervous system by engaging a CaMK…
Mechanisms that differentiate the capacity of newborn immune cells to orchestrate tissue regeneration are inadequately understood. Lantz et al. discover that in response to dying cells, neonatal macrophages synthesize and release pro-regenerative bioac…
Can bacteria that breach mucosal barriers drive long-lasting changes in immunity? In this issue of Immunity, Robles-Vera et al. describe how, in the context of colitis, bacteria breaching the intestinal barrier reprogram precursors in the bone marrow v…
In a recent work reported in Science, Zhang et al. untangle dynamic changes arising across aging in multiple cell populations within thirteen organs using single-cell transcriptomics and identify four distinct dynamic waves in which immune cells are th…
The enteric nervous system is a key regulator of inflammation, crosstalking directly with the immune system at the mucosal surfaces of the gastrointestinal tract. In this issue of Immunity, Wang and colleagues demonstrate that intrinsic enteric neurons…
