scRNA-seq has uncovered ontogenically distinct hepatic macrophage populations, but their functions remain unclear. Here, De Ponti et al. identify recruited LAMs and resident LAM-like KCs in multiple liver injury models and reveal that TREM2 expression …
Robles-Vera et al. unveil the capacity of gut microbiota translocation, particularly Enterococcus faecalis, to mediate a Mincle-dependent induction of trained immunity in myeloid bone marrow progenitors. This can be protective against subsequent infect…
(Immunity 57, 2380–2398.e1–e6; October 8, 2024)
Cryoglobulinemic vasculitis is a common complication of HCV infection. Young et al. reveal that three categories of somatic mutagenesis converge on a single B cell to generate pathogenic, autoantibody-producing clones in this virus-induced autoimmune d…
Far from homogeneous, neutrophils acquire remarkable diversity, particularly in the context of cancer. Ng, Cerezo-Wallis, Ng, and Hidalgo discuss the origin and mechanisms underlying the adaptation of neutrophils to cancer. They highlight intrinsic and…
Mitochondria play critical roles in intrinsic apoptosis and NLRP3 inflammasome activation, but how these processes are interconnected remains unclear. In this issue of Immunity, Saller et al. unveiled the complexity of NLRP3 activators, highlighting mi…
Interleukin-17 plays a major role in controlling adipose tissue homeostasis. In a recent study published in Nature, Douglas et al. demonstrate that time-of-day-dependent expression of interleukin-17 by tissue-resident innate lymphocytes in the adipose …
Ischemic stroke and vascular cognitive impairment are global health threats. Recent research has uncovered a previously underappreciated dynamic interplay between brain-resident, meningeal, and systemic immune cells. Iadecola and Anrather discuss the n…
Inhibiting T cell exhaustion is an attractive cancer immunotherapy strategy. In this issue of Immunity, Waibl Polania et al. examine the microenvironmental signals regulating terminal T cell exhaustion and find that antigen presentation by tumor-associ…
Immune activation during sustained stress typically worsens stress-related psychopathology. Whether it can enhance stress resilience remains unclear. In this issue of Immunity, Xia, Lu, Lan et al. uncover an anxiolytic function of intestinal IL-22 path…
