How immune and epithelial cells simultaneously fuel their dysfunction in chronic skin diseases is unclear. Subudhi and Konieczny et al. find that IL-17-induced epithelial HIF1α activates glycolysis, which potentiates the γδ T17 response via lactate. Th…
Cellular and molecular mechanisms leading to SLE are unclear. Li et al. show that SLE CD4+ T cells downregulate CBLs and ablation of CBLs in mouse T cells causes hyper Tfh cell responses and SLE. CBLs restrain Tfh cell responses by ubiquitinating ICOS,…
Pancreatic islet β cells are highly sensitive to autoinflammatory insults, in part due to their highly oxidative microenvironment. Srivastava et al. report that CXCL16 on resident islet macrophages scavenges OxLDL in pancreatic islets. This process, wh…
Ferroptosis is a distinct form of regulated cell death highlighted by the contributions of lipid peroxidation and iron. In this review, Zou and colleagues summarize and interpret the literature on the mechanism and role of ferroptosis in the context of…
Beyond their hemostatic roles, platelets are critical for host responses against pathogens. Dysregulated activation of these multitalented cells may also contribute to immunopathology with ensuing microvascular clotting, excessive innate immune respons…
Astrocytes respond to all forms of central nervous system maladies. In a recent issue of Nature, Lee et al. demonstrate that astrocytes encode inflammatory stimuli as epigenetic memory, which strengthens responses to subsequent stimuli and exacerbates …
The intestinal epithelium interacts with immune cells to support tissue homeostasis and coordinate responses against pathogens. In this issue of Immunity, Yang et al. unveil a central role for mast cell-epithelial cell interactions in orchestrating pro…
Stem cells heal wounds. In this issue of Immunity, Luan et al. demonstrate that epidermal stem cells orchestrate the recruitment of regulatory T (Treg) cells and neutrophils during wound healing. Treg cells facilitate a tolerogenic environment to prote…
The ubiquitin-binding endoribonuclease N4BP1 is a critical immunosuppressor, but the mechanism by which it acts to constrain TLR-induced inflammatory cytokine production has remained unclear. In this issue of Immunity, Gitlin et al. find that N4BP1 wor…
Humans do not respond equally to vaccination. To investigate why, Mulè et al. developed a multimodal framework and found that high responders after unadjuvanted influenza vaccination exist in a naturally adjuvanted state, mimicking innate immunophenoty…
