Immune response may be harnessed to control HIV, primary trial results suggest
Researchers led by Imperial have unveiled primary trial results that show encouraging advances in HIV treatment driven by immune-based therapies.
Medical Xpress
Controlling cell acidity could be key to autoimmune disease treatment
What if treating autoimmune diseases was as simple as regulating the acidity levels of parts of patients’ cells? Genetic screening may have unlocked a path for treating the severe inflammation associated with many immune diseases by regulating one prot…
How proteins guide plasma cells to bone marrow for long-term immunity
Vaccine effectiveness relies on creating a strong antibody response that can be reactivated to fight future infections. Now, researchers from Japan report that antibody-producing cells are destined for longevity from the moment they are born.
New test helps doctors predict a dangerous side effect of cancer treatment
Medical researchers in Japan have discovered a way to predict a potentially life-threatening side effect of cancer immunotherapy before it occurs. By analyzing cerebrospinal fluid collected pre-treatment, researchers at Kyushu University identified spe…
From inflammation to fibrosis: Research explores cellular changes as COVID-19 lung damage worsens
Researchers have uncovered changes in the cellular response throughout lung damage caused by SARS-CoV-2—the virus behind COVID-19. The team revealed distinct phases where waves of immune responses give way to lung fibrosis—scarring of the lungs—in seve…
FLIpping the switch: DNA regulator activates blood stem cells for improved transplantation success
A single molecular switch is essential for blood stem cells to enter an activated, regenerative state in which they produce new blood cells, according to a preclinical study led by Weill Cornell Medicine investigators. The discovery could lead to more …
Bladder macrophages form immune barrier against bloodstream infections, study finds
A research team led by Prof. Zeng Zhutian from the University of Science and Technology of China (USTC) has identified and named a novel population of bladder-resident macrophages, termed suburothelial perivascular macrophages (suPVMs), which can preve…
Genes combined with immune response to Epstein-Barr virus increase MS risk, study finds
In multiple sclerosis (MS), antibodies to the common Epstein-Barr virus can accidentally attack a protein in the brain and spinal cord. New research shows that the combination of certain viral antibodies and genetic risk factors can be linked to a grea…
Multi-dose vaccines administered in the same site boost immune response
New research suggests that receiving multiple doses of a vaccine in the same limb leads to faster antibody development, an important strategy for providing immunity as quickly as possible during a pandemic or disease outbreak.
Combination therapy tackles drug resistance in lung cancer with common KRAS mutation
A breakthrough in lung cancer treatment may be on the horizon. Scientists at VCU Massey Comprehensive Cancer Center have uncovered a powerful combination therapy leveraging sotorasib—an FDA-approved drug in the market—and an experimental drug called FG…