Study reveals how cancer immunotherapy may cause myocarditis in some patients
Some patients being treated with immune checkpoint inhibitors, a type of cancer immunotherapy, develop a dangerous form of heart inflammation called myocarditis.
Medical Xpress
Innate immune defense system plays an unexpected role in maintaining genome stability, researchers find
Along with defending against pathogens, the body’s innate immune system helps to protect the stability of our genomes in unexpected ways—ways that have important implications for the development of cancer, researchers at Memorial Sloan Kettering Cancer…
Scientists identify immune molecule that keeps metabolism in tune and on time
Recent research reveals that the immune system interacts with the body’s internal clock, influencing both fat storage and temperature regulation.
Moderate expression of CD39 in GPC3-CAR-T cells shows high efficacy against hepatocellular carcinoma
In the quest to enhance the efficacy of chimeric antigen receptor T (CAR-T) cell therapy against hepatocellular carcinoma (HCC), a study in Frontiers of Medicine has identified a pivotal role for CD39 expression in modulating the function of CAR-T cells.
Glioblastoma: Why immunotherapy may offer hope for brain cancer patients
Glioblastoma is the most common and deadliest form of brain cancer. Patients face a bleak prognosis—the average survival after diagnosis is between 12 and 15 months. And just 6.9% of patients survive beyond five years, making it one of the most poorly …
Brain immune cells amplify damage caused by Alzheimer’s risk gene, study finds
In healthy brains, immune cells called microglia patrol for damage, clearing away debris and harmful proteins. But in the presence of the APOE4 protein—the most important genetic risk factor for Alzheimer’s disease—the same cells cause harmful inflamma…
Antibody-based treatment for the most aggressive type of breast cancer could also treat other cancers
In a study published in Cell Reports, researchers from Prof. Idit Shachar’s laboratory at the Weizmann Institute of Science have discovered that a certain type of aggressive breast cancer prompts nearby immune cells to build “molecular bridges” between…
Berry-flavored vapes may paralyze immune cells in the lungs, study finds
Berry-flavored vapes can weaken the lungs’ natural defenses, making it harder for the body to fight off infections, research suggests. The study, published in Proceedings of the National Academy of Sciences, compared effects of flavored e-cigarettes to…
New AI tool identifies better antibody therapies
From sending cancer into remission to alleviating COVID-19 symptoms, immunotherapy can provide revolutionary disease treatments. Immunotherapies use antibodies—proteins that bind to cell markers called antigens—to target and eliminate the antigen. But …
Novel immunotherapy combo shows promise in melanoma
Pre-surgery treatment with the novel drug vidutolimod and the PD-1 checkpoint inhibitor nivolumab led to tumor control in 55% of patients with stage 3 cutaneous melanoma, according to the results of a single-arm phase 2 clinical trial led by the Univer…