Trends Immunol. 2024 Sep 25:S1471-4906(24)00211-4. doi: 10.1016/j.it.2024.09.003. Online ahead of print.
ABSTRACT
Thromboinflammation is a peculiar and key component of acute COVID-19 pathogenesis, which contributes to long COVID. In a recent study, Ryu et al. demonstrate that the SARS-CoV-2 spike protein interacts with fibrinogen, promoting fibrin polymerization and its inflammatory activity. Targeting the inflammatory fibrin peptide protected mice from spike-dependent fibrin clotting and neuropathology.
PMID:39327204 | DOI:10.1016/j.it.2024.09.003