Trends Immunol. 2024 Sep 25:S1471-4906(24)00213-8. doi: 10.1016/j.it.2024.09.005. Online ahead of print.
ABSTRACT
Cancers hijack the nervous system for growth and spread. Thus, disrupting neuron-cancer crosstalk holds promise for blocking metastasis. Recently, Padmanaban et al. reported new therapeutic targets and showed that breast cancer cells activate sensory neurons to secrete the neuropeptide substance P (SP), leading to single-strand (ss)RNA release and noncanonical Toll-like receptor (TLR)7 signaling that drives metastasis.
PMID:39327205 | DOI:10.1016/j.it.2024.09.005