Semin Immunol. 2025 Apr 9;78:101953. doi: 10.1016/j.smim.2025.101953. Online ahead of print.
ABSTRACT
Cellular stress responses are pivotal in maintaining tissue homeostasis and intricately linked with various diseases. Macrophages, a key player of innate immune system, exhibit remarkable plasticity and responsiveness to environmental cues. In response to various cellular stresses, macrophages contribute to tissue homeostasis and disease progression via specialized activation/polarization associated with distinctive phenotypes and functions. This review provides an overview of the intricate interplay between cellular stress responses and macrophage activation, summarizing recent advancements and offering insights into potential therapeutic strategies.
PMID:40215712 | DOI:10.1016/j.smim.2025.101953