Trends Immunol. 2026 Apr 23:S1471-4906(26)00095-5. doi: 10.1016/j.it.2026.04.002. Online ahead of print.
ABSTRACT
It remains unclear how mitochondrial stress instructs the transcriptional programme of terminal T cell exhaustion. In a recent study, Xu et al. uncovered a proteasome-haem-BACH2 axis in which haem liberated from damaged mitochondrial haemoproteins acts as a molecular messenger that couples mitochondrial injury to terminal T cell exhaustion.
PMID:42031636 | DOI:10.1016/j.it.2026.04.002