Trends Immunol. 2026 May 1:S1471-4906(26)00097-9. doi: 10.1016/j.it.2026.04.004. Online ahead of print.
ABSTRACT
Itaconate is an immunomodulatory metabolite that links metabolism and inflammation. Li et al. uncover a mechanism by which itaconate and 4-octyl itaconate suppress cytokine signaling through the alkylation of tyrosine kinase 2 and Janus kinase 1. This study reveals a direct metabolic control of inflammation and highlights its therapeutic potential in sepsis.
PMID:42069477 | DOI:10.1016/j.it.2026.04.004