Trends Immunol. 2026 Jun 5:S1471-4906(26)00127-4. doi: 10.1016/j.it.2026.05.002. Online ahead of print.
ABSTRACT
Neutrophil asthma is a severe, corticosteroid-resistant subtype characterized by airway neutrophilia and declining lung function. Su et al. identify a sirtuin 6-lactate dehydrogenase A-histone lactylation axis that links macrophage glycolysis to epigenetic chemokine regulation, offering mechanistic insight into neutrophil recruitment and highlighting potential therapeutic targets.
PMID:42248697 | DOI:10.1016/j.it.2026.05.002