Trends Immunol. 2026 Jun 9:S1471-4906(26)00132-8. doi: 10.1016/j.it.2026.05.007. Online ahead of print.
ABSTRACT
Pancreatic cancer is a deadly disease defined by an immunosuppressive microenvironment refractory to therapy. Kiemen et al. applied 3D histology, imaging mass cytometry, and spatially resolved DNA sequencing to human pancreata containing early precursors of the disease, revealing heterogeneous and mutation-specific inflammatory niches that are poorly resolved by 2D methods.
PMID:42265012 | DOI:10.1016/j.it.2026.05.007