Trends Immunol. 2026 Aug 1:S1471-4906(26)00187-0. doi: 10.1016/j.it.2026.07.008. Online ahead of print.
ABSTRACT
Spatial multi-omics of aging human lymph nodes by Fan and colleagues reveals that immunosenescence manifests as focal B cell coalescence into ‘SenSpots’ within germinal centers, where concerted epigenetic, transcriptional, proteomic, and metabolic reprogramming spatially orchestrates the decline of humoral immunity.
PMID:42538165 | DOI:10.1016/j.it.2026.07.008