Bryan C. Remaily – InmunoES

Fc gamma receptor binding modulates IgG clearance in cancer cachexia

31 de March de 2026 by Bryan C. Remaily

BackgroundPatients with cancer-cachexia display a general resistance to Immune Checkpoint Inhibitor (ICI) therapy, as well as an elevated baseline catabolic clearance (CL) of ICIs, which serves as a prognostic indicator of overall survival independent …

Tumor intrinsic properties dictate Fc receptor expression and cancer cachexia associated increase in checkpoint inhibitor clearance

17 de December de 2025 by Bryan C. Remaily

PurposePatients with cancer cachexia display a general resistance to immune checkpoint inhibitor (ICI) therapy, and baseline ICI catabolic clearance is a predictive indicator for overall survival, independent of dose and drug exposure. Fc-gamma (FcγRs)…