IntroductionSevere dengue infection is characterized by endothelial injury and systemic inflammatory complications. To better understand the mechanisms underlying disease severity, we investigated a broad panel of circulating inflammatory and endotheli…
BackgroundIntrahepatic cholangiocarcinoma (ICC) exhibits substantial cellular heterogeneity and a complex tumor microenvironment (TME), contributing to poor clinical outcomes. Effective prognostic biomarkers and a deeper understanding of the cellular e…
BackgroundH5N1 highly pathogenic avian influenza (HPAI) has been detected in multiple animal species, including humans, posing a significant threat to public health. Vaccines capable of eliciting robust mucosal and systemic immunity are needed to prote…
BackgroundPneumonia is the second most common infection in individuals with end-stage kidney disease and is associated with poor prognosis. The most frequently implicated pathogen is Streptococcus pneumoniae. Vaccine coverage is therefore essential. Di…
RationalSteroid-insensitive type 2 cytokine-producing CD8+ T cells (Tc2) are enriched in patients with severe asthma and correlate with disease severity, highlighting their potential role as drivers of treatment-refractory disease. The molecular mechan…
IntroductionAdult autoimmune neutropenia (AIN) is a rare and probably underrecognized immune cytopenia for which population-based adult incidence estimates are not established. Unlike the benign, self-limiting course seen in children, the adult traject…
BackgroundAutoimmune cerebellar ataxia (ACA) can cause substantial disability. Evidence regarding immunotherapy for ACA, including rituximab (RTX), remains limited. This study evaluated the association of RTX treatment with outcomes in nonparaneoplasti…
BackgroundBatch effects represent a major source of non-biological variability in clinical bead-based multiplex immunoassays (BBMIs), particularly when samples are processed across different analytical days and when measurements include a substantial p…
IntroductionIntraocular inflammation can arise from various conditions and can lead to severe vision loss and blindness. The differences in the intraocular immune response between infectious and autoimmune etiologies have not been defined.MethodsHere w…
The efficacy of immune checkpoint blockers in solid tumors remains limited by the physical and biological barriers posed by the tumor microenvironment, which restrict antibody transport and suppress anti-tumor immune responses. Focused ultrasound has e…
