BackgroundHead and neck squamous cell carcinoma (HNSC) is a highly heterogeneous malignancy with poor prognosis and frequent recurrence. Beyond tumor-intrinsic alterations, the immune microenvironment plays a decisive role in tumor initiation and progr…
BackgroundCOVID-19 vaccination has significantly reduced mortality and morbidity. Recent studies in unvaccinated people indicate a more complex immune response beyond just the cytokine storm. Understanding changes in the immune cell network is crucial …
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known as the etiological agent of coronavirus disease 2019 (COVID-19). Extrapulmonary manifestations of COVID-19 have gained increasing recognition as significant contributors to disease s…
Age-related hearing loss is a global public health issue that impacts the quality of life in the elderly population. Macrophages are the main immune cell population in the cochlea, yet the role in the development and progression of age-related hearing …
IntroductionE-cigarette use or “vaping” exposes the lungs to a large array of chemicals, flavors and nicotine. Initially marketed as a healthier alternative to tobacco use, research has since begun to demonstrate vaping plays a role in immune dysfuncti…
IntroductionThe role of antineuronal antibody titres in the acute and long-term diagnostic and therapeutic management of autoimmune encephalitis (AE) remains unclear. In this retrospective monocentric cohort study, we aimed to (I) identify specific cha…
ObjectiveIntervertebral disc degeneration (IDD) is a complex, multifactorial orthopedic disorder. This study aims to investigate the therapeutic effects and underlying mechanisms of quercetin (QUE), a key bioactive component of Achyranthis Bidentatae R…
ObjectiveImmune checkpoint inhibitors (ICIs) can induce immune system activation and cause immune-related adverse events (irAEs). This study aimed to assess the incidence and management of irAEs in thymoma patients with preexisting MG who received ICI …
ObjectiveThis study aimed to investigate the effects of different concentrations of tobacco smoke on airway remodeling and airway inflammation in mouse models of asthma with distinct inflammatory phenotypes.MethodsAsthmatic mouse models were establishe…
IntroductionAutoimmune hepatitis is a chronic inflammatory liver disease in which the immune system attacks liver tissue. While genetic predisposition plays a role, environmental factors are increasingly recognized as contributors to disease onset and …
