Chen, D.-W., Cheng, Y.-K., Li, P.-S., Wu, X.-J., Huang, X.-X., Long, J.-H., Xiong, Z., Chen, C., Ye, S.-B., Lan, P.

Tumor-intrinsic TTLL12 drives resistance to cancer immunotherapy via modulating myeloid-derived suppressor cells

3 de June de 2025 by Chen, D.-W., Cheng, Y.-K., Li, P.-S., Wu, X.-J., Huang, X.-X., Long, J.-H., Xiong, Z., Chen, C., Ye, S.-B., Lan, P.

Background
The majority of patients treated with immunotherapy as a standalone therapy experience little to no benefits. Tubulin tyrosine ligase 12 (TTLL12), as a member of the tubulin tyrosine ligase protein family, is associated with the prognosis o…