Chen, X., Zhang, J., Chen, H., Huang, R., Zhou, X., Wang, H., Xiao, H., Peng, Q., Wu, F., Zhai, Z., Wang, Z.

Targeting CD74 may mitigate immune-escape features and enhance BCMA CAR-T activity in preclinical models of relapsed/refractory multiple myeloma

14 de May de 2026 by Chen, X., Zhang, J., Chen, H., Huang, R., Zhou, X., Wang, H., Xiao, H., Peng, Q., Wu, F., Zhai, Z., Wang, Z.

Background
B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T-cell therapy has demonstrated substantial clinical benefit in relapsed/refractory multiple myeloma (R/R MM). Nonetheless, immune escape and therapeutic resistance r…