Cheng, Y., Zhao, Y., Liu, Y., Zhang, Y., Xu, D., Sun, W., Zhang, M., Miao, Y., He, S., Hou, Y., Stupack, D., Li, E.

Durable antitumor response via an oncolytic virus encoding decoy-resistant IL-18

5 de December de 2024 by Cheng, Y., Zhao, Y., Liu, Y., Zhang, Y., Xu, D., Sun, W., Zhang, M., Miao, Y., He, S., Hou, Y., Stupack, D., Li, E.

Background
Interleukin-18 (IL-18), or interferon (IFN)–inducing factor, potentiates T helper 1 and natural killer cell activation as well as CD8+ T-cell proliferation. Recombinant IL-18 has displayed limited clinical efficacy in part due to the expre…