PD-1 knockout on cytotoxic primary murine CD8+ T cells improves their motility in retrovirus infected mice
Cytotoxic T lymphocyte (CTL) motility is an important feature of effective CTL responses and is impaired when CTLs become exhausted, e.g. during chronic retroviral infections. A prominent T cell exhaustion marker is programmed cell death protein 1 (PD-…