Tumor cells express and maintain HMGB1 in the reduced isoform to enhance CXCR4-mediated migration
During inflammation and tissue regeneration, the alarmin High Mobility Group Box 1 (HMGB1), in its reduced isoform, enhances the activity of the chemokine CXCL12, forming a heterocomplex that acts via the chemokine receptor CXCR4. Despite the establish…