Collaboration between a cis-interacting natural killer cell receptor and membrane sphingolipid is critical for the phagocyte function
Inhibitory natural killer (NK) cell receptors recognize MHC class I (MHC-I) in trans on target cells and suppress cytotoxicity. Some NK cell receptors recognize MHC-I in cis, but the role of this interaction is uncertain. Ly49Q, an atypical Ly49 recept…