Molecular basis of anti-CD36 alloimmunization: transcriptomic evidence linking intronic splice-site mutations to CD36 loss-of-function
BackgroundCD36 deficiency is a genetic disorder that can lead to fetal/neonatal alloimmune thrombocytopenia or platelet transfusion refractoriness. While CD36 deficiency caused by exonic mutations are well established, the RNA splicing mechanism by int…