inmunoadmin

Cancer cells present aberrant glycosylation patterns that contribute to the evasion of antitumor immunity by triggering lectin receptors. Therefore, tumor glycosylation represents an interesting target for novel immunotherapy strategies. This review discusses the different mechanisms by which tumor-derived glycans induce tolerogenic programs in immune cells and their clinical significance. ABSTRACT Tumor immune escape refers to the … Read more

Clinical grade JIPh_Ec70 phages but not JIPh_Kp127 phages elicit a potent inflammatory response in peripheral immune cells. JIPh_Ec70 phagocytic engulfment is facilitated by complement opsonization, resulting in STING activation by phage DNA, driving an inflammatory signaling cascade. Understanding phage immunogenicity will be a key factor in developing effective phage therapies in the coming years. ABSTRACT … Read more

Patients with systemic lupus erythematosus (SLE) frequently have autoantibodies against the ORF1p protein encoded by the retrotransposon “long interspersed element-1” (LINE-1 or L1). Here, we report that type I interferon and other cytokines or toll-like receptor agonists induce a rapid increase in L1 transcripts and ORF1p in myeloid cells. ABSTRACT Approximately 17% of our genome … Read more

Immunosenescence and cytomegalovirus infection are suggested to impair protective immunity against novel pathogens. Despite reduced total CD8+ Tnaïve cells in older CMV– and CMV+ individuals, our study found a broad and robust memory SARS-CoV-2-specific CD8+ T cell response in both younger and older convalescent COVID-19 donors regardless of CMV status. ABSTRACT Immunosenescence, age-related immune dysregulation, … Read more

Several mouse strains have a genetic deficiency in the fifth component of complement (C5). This defect affects research outcomes in areas such as allergies, autoimmunity, cancer, infectious diseases, and inflammation. ABSTRACT The complement system is a crucial component of the innate immune response, playing a vital role in defending the body against pathogens and maintaining … Read more

The bacterium Prevotella timonensis found in vaginal dysbiosis enhances the uptake of HIV-1 by primary dendritic cells. Virus is internalised into tetraspanin-rich compartments, which leads to efficient HIV-1 transmission to target cells. These results provide insight into how microbiota directly affect HIV-1 uptake thereby altering HIV-1 susceptibility. Created in BioRender. Geijtenbeek, T. (2025) https://BioRender.com/i89c292. ABSTRACT … Read more

Multicolor spectral flow cytometry panels for cytokine expression analysis were optimized and validated without animal testing. Stimulated co-cultures of helper T cells, splenocytes, and fibroblast-like synoviocytes provided a complex cellular environment suitable for validating intracellular cytokine staining. This approach offers a more ethical alternative to commonly used animal disease models. ABSTRACT Intracellular cytokine labeling combined … Read more

The complement system plays a crucial role in immune defense, and factor D deficiency is a rare immunodeficiency associated with life-threatening bacterial infections. We report two new cases of complete factor D deficiency, including the first described in a Down syndrome patient, highlighting the need to investigate complement deficiencies in patients with secondary immunosuppression. Given … Read more