inmunoadmin

J Immunol. 2025 Jan 1;214(1):167-179. doi: 10.1093/jimmun/vkae017. ABSTRACT The von Hippel-Lindau (VHL) tumor suppressor gene VHL is a classic tumor suppressor that has been identified in family members with clear cell renal cell carcinomas, central nervous system and retinal hemangioblastomas, phaeochromocytomas, and pancreatic neuroendocrine tumors. The well-defined function of VHL is to mediate proteasomal degradation … Read more

J Immunol. 2025 Jan 1;214(1):85-103. doi: 10.1093/jimmun/vkae010. ABSTRACT Macrophages are critical to maintaining and restoring tissue homeostasis during inflammation. The lipid metabolic state of macrophages influences their function and polarization, which is crucial to the resolution of inflammation. The contribution of lipid synthesis to proinflammatory macrophage responses is well understood. However, how lipid synthesis regulates … Read more

J Immunol. 2025 Jan 1;214(1):130-140. doi: 10.1093/jimmun/vkae008. ABSTRACT While several African swine fever virus (ASFV)-encoded proteins potently interfere with the cGAS-STING (cyclic GMP-AMP synthetase-stimulator of interferon genes) pathway at different levels to suppress interferon (IFN) type I production in infected macrophages, systemic IFN-α is induced during the early stages of AFSV infection in pigs. The … Read more

J Immunol. 2025 Jan 1;214(1):115-129. doi: 10.1093/jimmun/vkae006. ABSTRACT As one of the earliest identified susceptible animals for the SARS-CoV-2, cats are also the vulnerable hosts for feline coronaviruses, ie feline enteric coronavirus (FECV). Here, to understand the cross-presentation of coronavirus-derived peptides by cat major histocompatibility complex molecule feline leucocyte antigen (FLA) class I, unpredictable natural … Read more

J Immunol. 2025 Jan 1;214(1):72-84. doi: 10.1093/jimmun/vkae005. ABSTRACT Decoy receptor 3 (DcR3), a soluble receptor in the tumor necrosis factor receptor superfamily, regulates the functions of monocytes, macrophages, dendritic cells, and T cells. Previous studies have demonstrated that DcR3 suppresses B cell proliferation in vitro and ameliorates autoimmune diseases in animal models; however, whether and … Read more

J Immunol. 2025 Jan 1;214(1):55-71. doi: 10.1093/jimmun/vkae002. ABSTRACT Poliovirus receptor (PVR) ligands have gained attention as immunotherapy targets, yet their regulation remains unclear. Here, we examine the impact of PVR exposure on primary human CD8+ T cells. We used flow cytometry and Western blot analysis to quantify expression of PVR and its ligands in naïve … Read more