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Limited proteolysis of neutrophil granule proteins by the bacterial protease RgpB depletes neutrophil antimicrobial capacity​. Kelley N Cooper

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J Leukoc Biol. 2024 Sep 25:qiae209. doi: 10.1093/jleuko/qiae209. Online ahead of print. ABSTRACT Neutrophils are highly abundant in the gingival tissues where they play an essential role in immune homeostasis by preventing microbial invasion. Here, we show that the oral periodontal pathogen Porphyromonas gingivalis utilizes its cysteine proteases (gingipains) to disengage phagosomal antimicrobial capacity. Arginine … Read more

The 129 strain-derived passenger mutations in ACKR1-deficient mice alter the expression of PYHIN and Fc-gamma receptor genes. ​Zoe Möller-Ramon

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J Leukoc Biol. 2024 Sep 25:qiae208. doi: 10.1093/jleuko/qiae208. Online ahead of print. ABSTRACT A majority of genetically modified mice have been produced using 129 strain-derived embryonic stem cells (ESCs). Despite ample backcrosses with other strains, these may retain characteristic for 129 passenger mutations leading to confounding phenotypes unrelated to targeted genes. Here we show that … Read more

Dendritic cell-specific deletion of PKCδ in offspring of allergic mothers prevents the predisposition for development of allergic lung inflammation in offspring. ​Jacquelyn D Lajiness

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J Leukoc Biol. 2024 Sep 23:qiae207. doi: 10.1093/jleuko/qiae207. Online ahead of print. ABSTRACT In humans and in mice, maternal allergy predisposes offspring to development of allergy. In murine models, increased levels of maternal β-glucosylceramides are both necessary and sufficient for the development of allergic predisposition in offspring. Furthermore, increased numbers of CD11b+ dendritic cell subsets … Read more

Neonatal neutrophils exhibit reduced NLRP3 inflammasome activation. ​Lou Martha Wackerbarth

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J Leukoc Biol. 2024 Sep 23:qiae206. doi: 10.1093/jleuko/qiae206. Online ahead of print. ABSTRACT Newborns are at high risk to develop sepsis. This is linked to innate immune responses at birth which are not completely adapted to postnatal life. Neutrophils are key players of innate immunity and exhibit a marked ontogenetic regulation of their functionality. Here, … Read more

Blood immune profiles reveal a CXCR3/CCR5 axis of dysregulation in early sepsis. ​David Kealy

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J Leukoc Biol. 2024 Sep 23:qiae204. doi: 10.1093/jleuko/qiae204. Online ahead of print. ABSTRACT We report on a pilot study exploring whether blood immune signatures can reveal early specific indicator profiles for patients meeting sepsis criteria upon hospital admission. We analysed samples of sepsis-suspected patients (N=20) and age-spanning healthy controls (N=12), using flow cytometry-based assays. We … Read more

IFNγ induces epithelial reprogramming driving CXCL11-mediated T cell migration​. Alessandro Cutilli

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J Leukoc Biol. 2024 Sep 20:qiae205. doi: 10.1093/jleuko/qiae205. Online ahead of print. ABSTRACT The cytokine interferon-gamma (IFNγ) plays a multifaceted role in intestinal immune responses ranging from anti- to pro-inflammatory depending on the setting. Here, using a 3D co-culture system based on human intestinal epithelial organoids, we explore the capacity of IFNγ-exposure to reprogram intestinal … Read more

Inflammation mediated by gut microbiome alterations promotes lung cancer development and an immunosuppressed tumor microenvironment

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Cancer Immunol Res. 2024 Sep 13. doi: 10.1158/2326-6066.CIR-24-0469. Online ahead of print. ABSTRACT Accumulating evidence indicates that the gut microbiome influences cancer progression and therapy. We recently showed that progressive changes in gut microbial diversity and composition are closely associated with tobacco-associated lung adenocarcinoma (LUAD) in a human-relevant mouse model. Furthermore, we demonstrated that the … Read more

PTPRZ1-targeting RNA CAR T cells exert antigen-specific and bystander antitumor activity in glioblastoma

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Cancer Immunol Res. 2024 Sep 13. doi: 10.1158/2326-6066.CIR-23-1094. Online ahead of print. ABSTRACT The great success of chimeric antigen receptor (CAR) T-cell therapy in the treatment of patients with B-cell malignancies has prompted its translation to solid tumors. In the case of glioblastoma (GBM), clinical trials have shown modest efficacy, but efforts to develop more … Read more

CD91 and its ligand gp96 confer cross-priming capabilities to multiple APCs during immune responses to nascent, emerging tumors

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Cancer Immunol Res. 2024 Sep 13. doi: 10.1158/2326-6066.CIR-24-0326. Online ahead of print. ABSTRACT During cancer immunosurveillance, dendritic cells (DCs) play a central role in orchestrating T-cell responses against emerging tumors. Capture of miniscule amounts of antigen along with tumor-initiated costimulatory signals can drive maturation of DCs. Expression of CD91 on DCs is essential in cross-priming … Read more

Integrated germline and somatic features reveal divergent immune pathways driving response to immune checkpoint blockade

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Cancer Immunol Res. 2024 Sep 10. doi: 10.1158/2326-6066.CIR-24-0164. Online ahead of print. ABSTRACT Immune Checkpoint Blockade (ICB) has revolutionized cancer treatment, however the mechanisms determining patient response remain poorly understood. Here, we used machine learning to predict ICB response from germline and somatic biomarkers and interpreted the learned model to uncover putative mechanisms driving superior … Read more

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