inmunoadmin

Increasing expression of dual-specificity phosphatase 12 mitigates oxygen-glucose deprivation/reoxygenation-induced neuronal apoptosis and inflammation through inactivation of the ASK1-JNK/p38 MAPK pathway. Jiaxuan He Siyuan Li Yunpeng Teng Hongfei Xiong Zhuang Wang Xiaoyao Han Wei Gong Ya Gao a Anesthesia & Comfort Medical Center, Xi’an International Medical Center Hospital, Xi’an, Shaanxi Province, Chinab Department of Pediatric Surgery, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province, China

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Volume 57, Issue 1, July 2024.

Type B thymomas in patients with myasthenia gravis display a distinctive pattern of αβ TCR and IL-7 receptor α expression on CD4+CD8+ thymocytes. Tianlai Wang Boyu Wang Xiaowu Fan Yixin Cai Lequn Li Shengling Fu Thoracic Surgery Laboratory, Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

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Volume 57, Issue 1, July 2024.

Toolkit for mapping the clonal landscape of tumor-infiltrating B cells. E O Serebrovskaya

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Semin Immunol. 2024 Mar;72:101864. doi: 10.1016/j.smim.2024.101864. Epub 2024 Jan 31. ABSTRACT Our current understanding of whether B cell involvement in the tumor microenvironment benefits the patient or the tumor – in distinct cancers, subcohorts and individual patients – is quite limited. Both statements are probably true in most cases: certain clonal B cell populations contribute … Read more

Durability of immune responses to SARS-CoV-2 infection and vaccination. Mehul S Suthar

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Semin Immunol. 2024 Jun 10;73:101884. doi: 10.1016/j.smim.2024.101884. Online ahead of print. ABSTRACT Infection with SARS-CoV-2 in humans has caused a pandemic of unprecedented dimensions. SARS-CoV-2 is primarily transmitted through respiratory droplets and targets ciliated epithelial cells in the nasal cavity, trachea, and lungs by utilizing the cellular receptor angiotensin-converting enzyme 2 (ACE2). The innate immune … Read more

Early life microbiome influences on development of the mucosal innate immune system. Aline Ignacio

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Semin Immunol. 2024 May 23;73:101885. doi: 10.1016/j.smim.2024.101885. Online ahead of print. ABSTRACT The gut microbiota is well known to possess immunomodulatory capacities, influencing a multitude of cellular signalling pathways to maintain host homeostasis. Although the formation of the immune system initiates before birth in a sterile environment, an emerging body of literature indicates that the … Read more

B cell clonality in cancer. E A Bryushkova

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Semin Immunol. 2024 Mar;72:101874. doi: 10.1016/j.smim.2024.101874. Epub 2024 Mar 19. ABSTRACT Carcinogenesis in the process of long-term co-evolution of tumor cells and immune environment essentially becomes possible due to incorrect decisions made, remembered, and reproduced by the immune system at the level of clonal populations of antigen-specific T- and B-lymphocytes. Tumor-immunity interaction determines the nature … Read more

Systems biology of B cells in COVID-19. Matthew C Woodruff

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Semin Immunol. 2024 Mar;72:101875. doi: 10.1016/j.smim.2024.101875. Epub 2024 Mar 14. ABSTRACT The integration of multi-‘omic datasets into complex systems-wide assessments has become a mainstay in immunologic investigation. This focus on high-dimensional data collection and analysis was on full display in the investigation of COVID-19, the respiratory illness resulting from infection by the novel coronavirus SARS-CoV-2. … Read more

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