inmunoadmin Massoni-Badosa et al. present a comprehensive human tonsil cell atlas, identifying 121 cell types and states through multimodal single-cell profiling. This atlas elucidates cell differentiation pathways and regulatory circuits, defines cell states, and…
Mutations of the CBP/p300 histone acetyltransferase (HAT) domain can be linked to leukemic transition in humans. Jaschke et al. reveal that a small-molecule inhibitor of the CBP/p300 histone acetyltransferase activity acutely mobilizes leukocytes from …
When and how T cells make effector or memory decisions is not fully resolved. Abadie, Clark, and Valanparambil et al. uncover a reversible epigenetic switch enabling memory cells to diverge early after activation or dedifferentiate from effector cells …
Although it is known that pro- and anti-inflammatory neutrophils exist, the mechanisms that dictate their polarization remain unclear. Gour et al. report that neutrophils express a canonical neuronal receptor, Mrgpra1, and a neuropeptide ligand, neurop…
Tuft cells are central regulators of type 2 immunity in the intestine. Eshleman et al. reveal that commensal bacterial-derived butyrate restricts stem cell development into tuft cells through the epigenetic-modifying enzyme HDAC3. The microbiota can th…
High-affinity cells are proposed to preferentially develop into long-lived plasma cells. Sutton et al. examine the differentiation of Ighg2A10 B cells, specific for the Plasmodium falciparum circumsporozoite protein (PfCSP), and find that cells initiat…
New research from Yale University has unveiled the complex cellular communication system that allows immune cells to mount responses to infection and cancer. The study, published in Nature Methods, reveals how different cells use cytokines to talk to each other to shape immune responses. Using a new computational method based on a causal inference framework, CINEMA-OT, the Yale … Read more
Scientists have known for decades that pregnancy requires a mother’s body to adjust so that her immune system does not attack the growing fetus as if it were a hostile foreign invader. Yet despite learning a great deal more about the immunology of pregnancy in recent years, a new study shows that the cellular cross-talk … Read more
Los investigadores señalan que el componente identificado en el sistema inmunológico se denomina ´Rinl´, y podría proporcionar un nuevo objetivo para el desarrollo de terapias inmunomoduladoras. 21/09/2023 Un equipo de investigación de MedUni Viena (Austria) ha descubierto una proteína inmunorreguladora que podría estar relacionada con el desarrollo de enfermedades autoinmunes, enfermedades complejas cuyas causas son … Read more
Un nuevo enfoque, descrito en monos, puede ayudar a las perspectivas de compatibilidad de órganos, incluso, cuando esta no sea muy eleva con los donantes y en ausencia de fármacos inmunosupresores. 14/09/2023 Los trasplantes exitosos de riñon dependen, en gran medida, de la compatibilidad biológica del donante y del receptor. Hallar el método para aumentar … Read more
