inmunoadmin

Inhibition of cellular NEDDylation partially alters the MHC class I immunopeptidome

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J Immunol. 2026 Oct 1;215(10):vkag258. doi: 10.1093/jimmun/vkag258. ABSTRACT Determining how chemotherapeutic drugs alter the MHC class I-associated immunopeptidome is essential for designing rational combinatorial therapies to enhance antitumor CD8+ T-cell activity, such as immune checkpoint inhibitor Abs. We investigated the impact of a first-in-class inhibitor of cellular NEDDylation, MLN4924, on self-peptide presentation using 2 human … Read more

Effects of natural killer cell depletion on innate and adaptive immune responses to COVID mRNA vaccination

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J Immunol. 2026 Oct 1;215(10):vkag266. doi: 10.1093/jimmun/vkag266. ABSTRACT This study assessed the role that natural killer (NK) cells play in a murine model of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike mRNA vaccination. Flow cytometric analyses revealed that mRNA vaccination results in recruitment and maturation of NK cells in the spleen. Primed (CD27+ CD11b+) … Read more

Myeloid-derived suppressor cells in hematologic malignancies: A current state of the field

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J Immunol. 2026 Oct 1;215(10):vkag249. doi: 10.1093/jimmun/vkag249. ABSTRACT Myeloid-derived suppressor cells are a pivotal component of the immunosuppressive tumor microenvironment in hematologic malignancies. Through diverse mechanisms, they promote disease progression, therapeutic resistance, and immune evasion. This comprehensive review synthesizes current evidence on the roles of myeloid-derived suppressor cells across major hematologic cancers and evaluates their … Read more

Synovial Fluid Immune Cell Landscape in Juvenile Idiopathic Arthritis. [[{“value”:”Viola Pitkänen, Bella Lappalainen, Marja Rytkönen‐Nissinen, Terhi Remes‐Pakarinen, Paula Vähäsalo, Milja Möttönen, Minna‐Maija Grönlund, Miika Arvonen, Liisa Kröger, Anna‐Mari Schroderus, Tuure Kinnunen”}]]

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Synovial fluid immune cells in juvenile idiopathic arthritis were profiled using single-cell multiomics and flow cytometry. The immune landscape in synovial fluid was markedly distinct from that of blood and was enriched for dendritic cells, CD56hi NK cells, γδ T cells, CD4+ T peripheral helper and regulatory T cells, tissue-resident memory CD8+ T cells, and … Read more

Parasite‐Derived IL‐33 Inhibitors Prevent Bleomycin‐Induced Lung Fibrosis. [[{“value”:”Samuele Di Carmine, Tania Frangova, Suzanne H. Hodge, Danielle J. Smyth, Tera Birchall, Josh Richards, Ian Newton, Sarah Kelly, Alice R. Savage, E. Suzanne Cohen, J. Simon C. Arthur, Henry J. McSorley”}]]

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Infection with the intestinal helminth Heligmosomoides polygyrus bakeri, or administration of the parasite products (HES), or administration of recombinant HpARI2+HpBARI_Hom2 can all suppress the development of lung fibrosis in the mouse bleomycin model, via suppression of the IL-33 pathway. Graphic abstract created in BioRender. McSorley, HJ. (2026) https://BioRender.com/8ag7ll4. ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a … Read more

Cover Story: Eur. J. Immunol. 10’26.

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Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more

PGE2 Enhances Human ILC3 Function but Constrains ILC2‐to‐ILC3 Plasticity. [[{“value”:”Lorenz Wirth, Whitney Weigel, Efthymia Kokkinou, Johan Kolmert, Anna‐Karin Johnsson, Alessandro Quaranta, Craig Wheelock, Mattias Jangard, Ram V. Pandey, Sven‐Erik Dahlén, Christopher Andrew Tibbitt, Thomas Hochdörfer, Jenny Mjösberg”}]]

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Distinct prostaglandin circuits regulate human ILC2 and ILC3 function. ILC3-derived PGE2 promotes type 3 cytokine production, whereas hybrid ILC2/3 generated during plasticity retain an inhibitory response to PGE2 despite acquiring ILC3-like features. ABSTRACT Type 2 innate lymphoid cells (ILC2) drive eosinophilic asthma, whereas ILC3 and plastic ILC2/3 states are implicated in neutrophilic and mixed granulocytic … Read more

Programmed cell death protein 1 (PD-1) regulates metabolic activity of regulatory T cells in ischemia-induced acute kidney injury

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J Immunol. 2026 Oct 1;215(10):vkag234. doi: 10.1093/jimmun/vkag234. ABSTRACT Immune checkpoint inhibitor (ICPI) therapy, targeting Programmed cell death protein 1 (PD-1) and its ligands PD-L1 and PD-L2, have revolutionized cancer care. However, ICPI is linked to immune-related adverse events, including nephropathy manifesting as acute kidney injury (AKI), a rapid decline in kidney function, often progressing to … Read more

4-Octyl itaconate suppresses IFN-γ-induced MHC II expression in bone marrow-derived macrophages

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J Immunol. 2026 Oct 1;215(10):vkag255. doi: 10.1093/jimmun/vkag255. ABSTRACT Macrophages function as professional antigen-presenting cells that integrate inflammatory signals with metabolic reprogramming to shape immune responses. Itaconate, an immunometabolite derived from ACOD1/IRG1 activity in activated macrophages, has been implicated in the regulation of inflammatory responses, yet its role in interferon γ (IFN-γ)-driven antigen presentation programs remains … Read more

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