Activating an interleukin 4-FLT3-STAT6 axis in multipotent progenitors restores lymphopoiesis in inflammation and aging
Chronic inflammation and aging skew hematopoiesis toward myelopoiesis. Starting with a screen to identify signals capable of restoring lymphoid lineage commitment in HSPCs, Yao et al. find that exogenous interleukin 4 can drive lymphoid differentiation…