Khaniya, A., Rad, S. M. A. H., Halpin, J., Tawinwung, S., McLellan, A., Suppipat, K., Hirankarn, N.

Development of a compact bidirectional promoter-driven dual chimeric antigen receptor (CAR) construct targeting CD19 and CD20 in the Sleeping Beauty (SB) transposon system

27 de April de 2024 by Khaniya, A., Rad, S. M. A. H., Halpin, J., Tawinwung, S., McLellan, A., Suppipat, K., Hirankarn, N.

Background
A bidirectional promoter-driven chimeric antigen receptor (CAR) cassette provides the simultaneous expression of two CARs, which significantly enhances dual antigen-targeted CAR T-cell therapy.

Methods
We developed a second-generation CAR …