Lung-specific interleukin 6 mediated transglutaminase 2 activation and cardiopulmonary fibrogenesis
Pulmonary hypertension (PH) pathogenesis is driven by inflammatory and metabolic derangements as well as glycolytic reprogramming. Induction of both interleukin 6 (IL6) and transglutaminase 2 (TG2) expression participates in human and experimental card…