Antibodies directed against extracellular loops of FadL orthologs disrupt outer membrane integrity and neutralize infectivity of Treponema pallidum, the syphilis spirochete
A vaccine is urgently needed to curtail the global epidemic of syphilis, a sexually transmitted infection caused by the spirochetal pathogen Treponema pallidum (TPA). Protective antibodies must target extracellular loops (ECLs) of TPA outer membrane pr…