Li, W., Sun, J., Tian, H., Tang, X., Gao, L., Liang, S., Zhang, Z., Sun, Y., Ma, J., Zhao, X.

Dual-chemokine-armed oncolytic Senecavirus A co-recruits cDC1 and CXCR3+ T cells to convert ‘cold melanoma and drive durable regression

31 de March de 2026 by Li, W., Sun, J., Tian, H., Tang, X., Gao, L., Liang, S., Zhang, Z., Sun, Y., Ma, J., Zhao, X.

Background
Oncolytic virotherapy represents a promising anticancer strategy by combining direct tumor lysis with in situ immune activation. However, its efficacy remains limited in immune-cold tumors, which are characterized by poor T-cell infiltratio…