Li, X.-N., Wang, F., Chen, K., Wu, Z., Zhang, R., Xiao, C., Zhao, F., Wang, D., Zhao, H., Ran, Y., Qu, C.

XCL1-secreting CEA CAR-T cells enhance endogenous CD8+ T cell responses to tumor neoantigens to confer a long-term antitumor immunity

7 de January de 2025 by Li, X.-N., Wang, F., Chen, K., Wu, Z., Zhang, R., Xiao, C., Zhao, F., Wang, D., Zhao, H., Ran, Y., Qu, C.

Background
Therapeutic efficacy of carcinoembryonic antigen (CEA)-specific chimeric antigen receptor (CAR) T cells against colorectal cancer (CRC) remains limited due to the unique characteristics and distinct microenvironments of tumor tissues. We mo…