Lian, W., Yang, H., Zhang, Y., Liu, C., Fang, C., Xu, M., Yang, Y., Wang, Y., Jiang, R., Xu, J., Gao, W.

Targeting the PD-L1-induced PDK4/GLS metabolic axis overcomes anti-PD-1 resistance in non-small cell lung cancer

2 de September de 2026 by Lian, W., Yang, H., Zhang, Y., Liu, C., Fang, C., Xu, M., Yang, Y., Wang, Y., Jiang, R., Xu, J., Gao, W.

Background
Metabolic reprogramming within the tumor microenvironment is a pivotal barrier to effective immune checkpoint blockade (ICB). While programmed death ligand 1 (PD-L1) is well characterized as a ligand inhibiting T-cell function, its intrinsi…