Lin, C.-I., Chiu, Y.-W., Yen, M.-S., Wang, Y.-W., Wu, Y.-H., Chuang, Y.-H.

Liver-directed AAV-IL-10 therapy enhances CD8+ T cell-mediated immunity against hepatocellular carcinoma

27 de March de 2026 by Lin, C.-I., Chiu, Y.-W., Yen, M.-S., Wang, Y.-W., Wu, Y.-H., Chuang, Y.-H.

Background
The liver’s inherently immunosuppressive microenvironment presents a major barrier to effective immunotherapy for hepatocellular carcinoma (HCC). Although interleukin-10 (IL-10) has demonstrated antitumor activity in several cancer mo…