Lin, X., Zhang, J., Fan, Z., Yang, J., Yi, S., Wang, H., Zou, H., Hu, L., Zhu, W., Lin, Y., Hu, J., Cai, J., Yan, G., Liang, J.

Anti-CTLA-4 antibody potentiates the antitumor effect of armed oncolytic virus OVM18 via enhancing intratumoral IL-18R1+CD8+ T cells

7 de September de 2026 by Lin, X., Zhang, J., Fan, Z., Yang, J., Yi, S., Wang, H., Zou, H., Hu, L., Zhu, W., Lin, Y., Hu, J., Cai, J., Yan, G., Liang, J.

Background
Oncolytic virus M1 encoding a mutant IL-18 decoy (OVM18) represents a novel virotherapy that integrates selective oncolysis with localized activation of the IL-18 pathway. However, the heterogeneity of therapeutic responses suggests that ho…