Lin, Y., Chen, Z., Zhao, S., Zhao, L., Yang, C., Zhu, M., Ye, Y., Wang, S., Shen, Z.

Targeting SPP1+TAMs associated with liver metastasis reverses immunosuppression and synergizes with immunotherapy in colorectal cancer

25 de March de 2026 by Lin, Y., Chen, Z., Zhao, S., Zhao, L., Yang, C., Zhu, M., Ye, Y., Wang, S., Shen, Z.

Background
Tumor-associated macrophages (TAMs) are critically involved in colorectal cancer (CRC) progression, yet their spatial and metabolic heterogeneity across primary and metastatic microenvironments remains poorly defined, limiting therapeutic d…