Lv, L., Miao, Q., Zhan, S., Chen, P., Liu, W., Lv, J., Yan, W., Wang, D., Liu, H., Yin, J., Feng, J., Song, Y., Ye, M., Lv, T.

LKB1 dictates sensitivity to immunotherapy through Skp2-mediated ubiquitination of PD-L1 protein in non-small cell lung cancer

18 de December de 2024 by Lv, L., Miao, Q., Zhan, S., Chen, P., Liu, W., Lv, J., Yan, W., Wang, D., Liu, H., Yin, J., Feng, J., Song, Y., Ye, M., Lv, T.

Background
Loss-of-function mutations of liver kinase B (LKB1, also termed as STK11 (serine/threonine kinase 11)) are frequently detected in patients with non-small cell lung cancer (NSCLC). The LKB1 mutant NSCLC was refractory to almost all the antit…