Ma, Z., Hao, X., Qu, S., Zhang, Q., Luo, J., Li, H., Liu, J., Dai, W., Li, J., Gu, S., Zhu, D., Chen, M., Zen, K.

Siglec-15 antibody-GM-CSF chimera suppresses tumor progression via reprogramming tumor-associated macrophages

11 de April de 2025 by Ma, Z., Hao, X., Qu, S., Zhang, Q., Luo, J., Li, H., Liu, J., Dai, W., Li, J., Gu, S., Zhu, D., Chen, M., Zen, K.

Background
Sialic acid-binding immunoglobulin-like lectin (Siglec)-15-expressing tumor-associated macrophages (TAMs) drive immunosuppression in the tumor microenvironment (TME), promoting CD8+ T cell exhaustion and limiting immunotherapy efficacy. Bot…