Computational characterization of peptide binding stability to HLA-C allotypes and its association with HIV-1 infection progression and HIV-1 related neurocognitive impairment
BackgroundHLA-C molecules play a critical role in the immune response, particularly in antigen presentation and immune modulation.MethodsTo investigate the effect of the most common HLA-C allotypes on the stability of the HLA-C-β-2 microglobulin-peptid…